{"id":8605,"date":"2025-05-15T03:02:12","date_gmt":"2025-05-15T03:02:12","guid":{"rendered":"https:\/\/changhongchemical.com\/?p=8605"},"modified":"2026-04-27T11:18:17","modified_gmt":"2026-04-27T11:18:17","slug":"applications-of-oxetane","status":"publish","type":"post","link":"https:\/\/changhongchemical.com\/pt\/applications-of-oxetane\/","title":{"rendered":"Aplica\u00e7\u00f5es do oxetano"},"content":{"rendered":"1. Lowering LogD to increase water solubility\r\nChanging the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water solubility . Introducing oxetane at different positions in the molecule has different effects on LogD and water solubility.\r\n\r\n2. Effect on pKa\r\nThe polar nature of oxetane can be used to modulate the base of the proximal amine. pKa decreases depending on the topological distance between the two functional units. When the methylene unit is replaced by an oxetane unit, the amino group at the \u03b1-position shows the largest decrease in pKa (between -2.5 and -3.5).\r\n\r\n3. Substitution of morpholine or other carbonyl-based structures in the block\r\nThe aqueous solubility of lipophilic scaffolds is often improved by the incorporation of morpholine structures, even though it is known that morpholine may be a target for oxidative metabolism. There are 17 commercially available APIs that contain a morpholine fraction. Metabolic data have been published for 13 of these compounds, and oxidative degradation of the morpholine peptide ring is the major metabolic pathway in eight of them. Spiro epoxetanes can be regarded as structural analogues of morpholine because of their ability to increase solubility while maintaining stability in oxidative metabolism. Thus, these oxetane derivatives are known as useful alternative building blocks to morpholine or other carbonyl-like structures through their unique polar spatial distribution.\r\n\r\n4. Substitution of morpholine or other carbonyl-based structures in the block\r\nThe aqueous solubility of lipophilic scaffolds is often improved by the incorporation of morpholine structures, even though it is known that morpholine may be a target for oxidative metabolism. There are 17 commercially available APIs that contain a morpholine fraction. Metabolic data have been published for 13 of these compounds, and oxidative degradation of the morpholine peptide ring is the major metabolic pathway in eight of them. Spiro epoxetanes can be regarded as structural analogues of morpholine because of their ability to increase solubility while maintaining stability in oxidative metabolism. Thus, these oxetane derivatives are known as useful alternative building blocks to morpholine or other carbonyl-like structures through their unique polar spatial distribution.\r\n

Entre em contato conosco agora!<\/b><\/strong><\/h1>\r\n

Se precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@changhongchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\n\n\n

Refer\u00eancias de produtos relacionados:<\/strong> Para an\u00e1lise de formula\u00e7\u00f5es ou compara\u00e7\u00e3o de fornecedores, consulte CHLUMICRYL 201<\/a> e CHLUMICRYL 203<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

1. Lowering LogD to increase water solubility Changing the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water solubility . Introducing oxetane at different positions in the molecule…<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[151],"tags":[],"class_list":["post-8605","post","type-post","status-publish","format-standard","hentry","category-pharmaceutical-intermediates"],"yoast_head":"\nApplications of oxetane - Changhong Chemical<\/title>\n<meta name=\"description\" content=\"1. Lowering LogD to increase water solubility Changing the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/changhongchemical.com\/pt\/applications-of-oxetane\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Applications of oxetane - Changhong Chemical\" \/>\n<meta property=\"og:description\" content=\"1. Lowering LogD to increase water solubility Changing the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/changhongchemical.com\/pt\/applications-of-oxetane\/\" \/>\n<meta property=\"og:site_name\" content=\"Changhong Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-15T03:02:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-27T11:18:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/changhongchemical.com\/wp-content\/uploads\/2024\/02\/logo-jpeg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Changhong Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Changhong Chemical\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/\"},\"author\":{\"name\":\"Changhong Chemical\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#\\\/schema\\\/person\\\/2a9593ff69d6db8f8ca0567ca3ed6b5d\"},\"headline\":\"Applications of oxetane\",\"datePublished\":\"2025-05-15T03:02:12+00:00\",\"dateModified\":\"2026-04-27T11:18:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/\"},\"wordCount\":406,\"publisher\":{\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#organization\"},\"articleSection\":[\"Pharmaceutical intermediates\"],\"inLanguage\":\"pt-BR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/\",\"url\":\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/\",\"name\":\"Applications of oxetane - Changhong Chemical\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#website\"},\"datePublished\":\"2025-05-15T03:02:12+00:00\",\"dateModified\":\"2026-04-27T11:18:17+00:00\",\"description\":\"1. Lowering LogD to increase water solubility Changing the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water...\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/applications-of-oxetane\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/changhongchemical.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Applications of oxetane\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#website\",\"url\":\"https:\\\/\\\/changhongchemical.com\\\/\",\"name\":\"Changhong Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/changhongchemical.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#organization\",\"name\":\"Changhong Chemical\",\"url\":\"https:\\\/\\\/changhongchemical.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/changhongchemical.com\\\/wp-content\\\/uploads\\\/2020\\\/08\\\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\\\/\\\/changhongchemical.com\\\/wp-content\\\/uploads\\\/2020\\\/08\\\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Changhong Chemical\"},\"image\":{\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/changhongchemical.com\\\/#\\\/schema\\\/person\\\/2a9593ff69d6db8f8ca0567ca3ed6b5d\",\"name\":\"Changhong Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a2d60a3a1fe3f833b6f3c104e1ab60f8bd057928e36187909c92dc89c162e333?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a2d60a3a1fe3f833b6f3c104e1ab60f8bd057928e36187909c92dc89c162e333?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a2d60a3a1fe3f833b6f3c104e1ab60f8bd057928e36187909c92dc89c162e333?s=96&d=mm&r=g\",\"caption\":\"Changhong Chemical\"},\"sameAs\":[\"https:\\\/\\\/changhongchemical.com\"],\"url\":\"https:\\\/\\\/changhongchemical.com\\\/pt\\\/author\\\/infolongchangchemical-com\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Aplica\u00e7\u00f5es do oxetano - Changhong Chemical","description":"1. Lowering LogD to increase water solubility Changing the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water...","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/changhongchemical.com\/pt\/applications-of-oxetane\/","og_locale":"pt_BR","og_type":"article","og_title":"Applications of oxetane - Changhong Chemical","og_description":"1. Lowering LogD to increase water solubility Changing the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water...","og_url":"https:\/\/changhongchemical.com\/pt\/applications-of-oxetane\/","og_site_name":"Changhong Chemical","article_published_time":"2025-05-15T03:02:12+00:00","article_modified_time":"2026-04-27T11:18:17+00:00","og_image":[{"width":1000,"height":1000,"url":"https:\/\/changhongchemical.com\/wp-content\/uploads\/2024\/02\/logo-jpeg.jpg","type":"image\/jpeg"}],"author":"Changhong Chemical","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"Changhong Chemical","Est. tempo de leitura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/changhongchemical.com\/applications-of-oxetane\/#article","isPartOf":{"@id":"https:\/\/changhongchemical.com\/applications-of-oxetane\/"},"author":{"name":"Changhong Chemical","@id":"https:\/\/changhongchemical.com\/#\/schema\/person\/2a9593ff69d6db8f8ca0567ca3ed6b5d"},"headline":"Applications of oxetane","datePublished":"2025-05-15T03:02:12+00:00","dateModified":"2026-04-27T11:18:17+00:00","mainEntityOfPage":{"@id":"https:\/\/changhongchemical.com\/applications-of-oxetane\/"},"wordCount":406,"publisher":{"@id":"https:\/\/changhongchemical.com\/#organization"},"articleSection":["Pharmaceutical intermediates"],"inLanguage":"pt-BR"},{"@type":"WebPage","@id":"https:\/\/changhongchemical.com\/applications-of-oxetane\/","url":"https:\/\/changhongchemical.com\/applications-of-oxetane\/","name":"Aplica\u00e7\u00f5es do oxetano - Changhong Chemical","isPartOf":{"@id":"https:\/\/changhongchemical.com\/#website"},"datePublished":"2025-05-15T03:02:12+00:00","dateModified":"2026-04-27T11:18:17+00:00","description":"1. Lowering LogD to increase water solubility Changing the carbonyl group and kai-dimethyl in the molecule to oxetane can reduce LogD and increase water...","breadcrumb":{"@id":"https:\/\/changhongchemical.com\/applications-of-oxetane\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/changhongchemical.com\/applications-of-oxetane\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/changhongchemical.com\/applications-of-oxetane\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/changhongchemical.com\/"},{"@type":"ListItem","position":2,"name":"Applications of oxetane"}]},{"@type":"WebSite","@id":"https:\/\/changhongchemical.com\/#website","url":"https:\/\/changhongchemical.com\/","name":"Qu\u00edmica Longchang","description":"Fabricante de produtos qu\u00edmicos na China \uff06 fornecedor","publisher":{"@id":"https:\/\/changhongchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/changhongchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":"Organization","@id":"https:\/\/changhongchemical.com\/#organization","name":"Qu\u00edmica Longchang","url":"https:\/\/changhongchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/changhongchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/changhongchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/changhongchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Changhong Chemical"},"image":{"@id":"https:\/\/changhongchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/changhongchemical.com\/#\/schema\/person\/2a9593ff69d6db8f8ca0567ca3ed6b5d","name":"Qu\u00edmica Longchang","image":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/secure.gravatar.com\/avatar\/a2d60a3a1fe3f833b6f3c104e1ab60f8bd057928e36187909c92dc89c162e333?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a2d60a3a1fe3f833b6f3c104e1ab60f8bd057928e36187909c92dc89c162e333?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a2d60a3a1fe3f833b6f3c104e1ab60f8bd057928e36187909c92dc89c162e333?s=96&d=mm&r=g","caption":"Changhong Chemical"},"sameAs":["https:\/\/changhongchemical.com"],"url":"https:\/\/changhongchemical.com\/pt\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/posts\/8605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/comments?post=8605"}],"version-history":[{"count":6,"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/posts\/8605\/revisions"}],"predecessor-version":[{"id":10047,"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/posts\/8605\/revisions\/10047"}],"wp:attachment":[{"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/media?parent=8605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/categories?post=8605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/changhongchemical.com\/pt\/wp-json\/wp\/v2\/tags?post=8605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}